Identification of chemical modulators of the constitutive activated receptor (CAR) in a gene expression compendium

The nuclear receptor family member constitutive activated receptor (CAR) is activated by structurally diverse drugs and environmentally-relevant chemicals leading to transcriptional regulation of genes involved in xenobiotic metabolism and transport. Chronic activation of CAR increases liver cancer...

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Veröffentlicht in:Nucl Recept Signal
Hauptverfasser: Oshida, Keiyu, Vasani, Naresh, Jones, Carlton, Moore, Tanya, Hester, Susan, Nesnow, Stephen, Auerbach, Scott, Geter, David R., Aleksunes, Lauren M., Thomas, Russell S., Applegate, Dawn, Klaassen, Curtis D., Corton, J. Christopher
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nuclear Receptor Signaling Atlas 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4422105/
https://ncbi.nlm.nih.gov/pubmed/25949234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1621/nrs.13002
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