Safety and immunogenicity of a Pseudomonas aeruginosa O-polysaccharide toxin A conjugate vaccine in humans.

Lipid A-free polysaccharide (PS) isolated from Pseudomonas aeruginosa immunotype 5 lipopolysaccharide (LPS) was covalently coupled to toxin A via reductive amination. The PS-toxin A conjugate was comprised of 29.8% PS and 70.2% toxin A, possessed a molecular weight of greater than 1 X 10(6), was non...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Cryz, S J, Fürer, E, Cross, A S, Wegmann, A, Germanier, R, Sadoff, J C
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 1987
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC442200/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3110215/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI113062
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