Paroxysmal nocturnal hemoglobinuria type III. Lack of an erythrocyte membrane protein restricting the lysis by C5b-9.

The complement-mediated lysis is inefficient when complement and target cells are homologous with regard to the species. In erythrocytes from patients suffering from paroxysmal nocturnal hemoglobinuria (PNH), the species restriction is lost: PNH-erythrocytes (PNH-E) are susceptible to lysis by human...

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Pubblicato in:	J Clin Invest
Autori principali:	Hänsch, G M, Schönermark, S, Roelcke, D
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 1987
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC442194/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3597779/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI113065
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