A REDD1/TXNIP pro-oxidant complex regulates ATG4B activity to control stress-induced autophagy and sustain exercise capacity

Macroautophagy (autophagy) is a critical cellular stress response; however, the signal transduction pathways controlling autophagy induction in response to stress are poorly understood. Here we reveal a new mechanism of autophagy control whose deregulation disrupts mitochondrial integrity and energy...

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Publicado en:Nat Commun
Autores principales: Qiao, Shuxi, Dennis, Michael, Song, Xiufeng, Vadysirisack, Douangsone D., Salunke, Devika, Nash, Zachary, Yang, Zhifen, Liesa, Marc, Yoshioka, Jun, Matsuzawa, Shu-Ichi, Shirihai, Orian S., Lee, Richard T., Reed, John C., Ellisen, Leif W.
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Pub. Group 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4421852/
https://ncbi.nlm.nih.gov/pubmed/25916556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8014
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