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An Efficient Method to Generate Chromosomal Rearrangements by Targeted DNA Double-Strand Breaks in Drosophila melanogaster

Homologous recombination (HR) is an indispensable tool to modify the genome of yeast and mammals. More recently HR is also being used for gene targeting in Drosophila. Here we show that HR can be used efficiently to engineer chromosomal rearrangements such as pericentric and paracentric inversions a...

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Библиографические подробности
Главные авторы: Egli, Dieter, Hafen, Ernst, Schaffner, Walter
Формат: Artigo
Язык:Inglês
Опубликовано: Cold Spring Harbor Laboratory Press 2004
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC442155/
https://ncbi.nlm.nih.gov/pubmed/15197166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.2279804
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