Munc18c mediates exocytosis of pre-docked and newcomer insulin granules underlying biphasic glucose stimulated insulin secretion in human pancreatic beta-cells

OBJECTIVE: Pancreatic beta-cells express three Munc18 isoforms. Much is known about the roles of Munc18a (pre-docked secretory granules-SGs) and Munc18b (newcomer SGs and SG–SG fusion) in insulin exocytosis. Although shown to influence glucose-stimulated insulin secretion (GSIS) in rodents the preci...

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Publicado en:Mol Metab
Main Authors: Zhu, Dan, Xie, Li, Karimian, Negar, Liang, Tao, Kang, Youhou, Huang, Ya-Chi, Gaisano, Herbert Y.
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2015
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4421095/
https://ncbi.nlm.nih.gov/pubmed/25973389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2015.02.004
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