Quantification of [(18)F]DPA-714 binding in the human brain: initial studies in healthy controls and Alzheimer's disease patients

Fluorine-18 labelled N,N-diethyl-2-(2-[4-(2-fluoroethoxy)phenyl]-5,7-dimethylpyrazolo[1,5-α]pyrimidine-3-yl)acetamide ([(18)F]DPA-714) binds to the 18-kDa translocator protein (TSPO) with high affinity. The aim of this initial methodological study was to develop a plasma input tracer kinetic model f...

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Detalhes bibliográficos
Publicado no:J Cereb Blood Flow Metab
Main Authors: Golla, Sandeep S V, Boellaard, Ronald, Oikonen, Vesa, Hoffmann, Anja, van Berckel, Bart N M, Windhorst, Albert D, Virta, Jere, Haaparanta-Solin, Merja, Luoto, Pauliina, Savisto, Nina, Solin, Olof, Valencia, Ray, Thiele, Andrea, Eriksson, Jonas, Schuit, Robert C, Lammertsma, Adriaan A, Rinne, Juha O
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4420859/
https://ncbi.nlm.nih.gov/pubmed/25649991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2014.261
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