SERCA1 overexpression minimizes skeletal muscle damage in dystrophic mouse models

Duchenne muscular dystrophy (DMD) is characterized by progressive muscle wasting secondary to repeated muscle damage and inadequate repair. Elevations in intracellular free Ca(2+) have been implicated in disease progression, and sarcoplasmic/endoplasmic reticulum Ca(2+)-ATPase 1 (SERCA1) overexpress...

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Bibliographic Details
Published in:Am J Physiol Cell Physiol
Main Authors: Mázala, Davi A. G., Pratt, Stephen J. P., Chen, Dapeng, Molkentin, Jeffery D., Lovering, Richard M., Chin, Eva R.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4420794/
https://ncbi.nlm.nih.gov/pubmed/25652448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00341.2014
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