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Aromatic cluster mutations produce focal modulations of β-sheet structure
Site-directed mutagenesis is a powerful tool for altering the structure and function of proteins in a focused manner. Here, we examined how a model β-sheet protein could be tuned by mutation of numerous surface-exposed residues to aromatic amino acids. We designed these aromatic side chain “clusters...
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| Publicado no: | Protein Sci |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BlackWell Publishing Ltd
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4420532/ https://ncbi.nlm.nih.gov/pubmed/25645104 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2657 |
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