Structural basis for the inhibition of M1 family aminopeptidases by the natural product actinonin: Crystal structure in complex with E. coli aminopeptidase N

Actinonin is a pseudotripeptide that displays a high affinity towards metalloproteases including peptide deformylases (PDFs) and M1 family aminopeptidases. PDF and M1 family aminopeptidases belong to thermolysin-metzincin superfamily. One of the major differences in terms of substrate binding pocket...

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Vydáno v:Protein Sci
Hlavní autoři: Ganji, Roopa Jones, Reddi, Ravikumar, Gumpena, Rajesh, Marapaka, Anil Kumar, Arya, Tarun, Sankoju, Priyanka, Bhukya, Supriya, Addlagatta, Anthony
Médium: Artigo
Jazyk:Inglês
Vydáno: BlackWell Publishing Ltd 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4420530/
https://ncbi.nlm.nih.gov/pubmed/25644575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2653
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