Overlapping Patterns of Rapid Evolution in the Nucleic Acid Sensors cGAS and OAS1 Suggest a Common Mechanism of Pathogen Antagonism and Escape

A diverse subset of pattern recognition receptors (PRRs) detects pathogen-associated nucleic acids to initiate crucial innate immune responses in host organisms. Reflecting their importance for host defense, pathogens encode various countermeasures to evade or inhibit these immune effectors. PRRs di...

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Publicat a:PLoS Genet
Autors principals: Hancks, Dustin C., Hartley, Melissa K., Hagan, Celia, Clark, Nathan L., Elde, Nels C.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2015
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4420275/
https://ncbi.nlm.nih.gov/pubmed/25942676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005203
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