cGAS-mediated stabilization of IFI16 promotes innate signaling during herpes simplex virus infection

Interferon γ-inducible protein 16 (IFI16) and cGMP-AMP synthase (cGAS) have both been proposed to detect herpesviral DNA directly in herpes simplex virus (HSV)-infected cells and initiate interferon regulatory factor-3 signaling, but it has been unclear how two DNA sensors could both be required for...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Orzalli, Megan H., Broekema, Nicole M., Diner, Benjamin A., Hancks, Dustin C., Elde, Nels C., Cristea, Ileana M., Knipe, David M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4394261/
https://ncbi.nlm.nih.gov/pubmed/25831530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1424637112
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