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cGAS-mediated stabilization of IFI16 promotes innate signaling during herpes simplex virus infection
Interferon γ-inducible protein 16 (IFI16) and cGMP-AMP synthase (cGAS) have both been proposed to detect herpesviral DNA directly in herpes simplex virus (HSV)-infected cells and initiate interferon regulatory factor-3 signaling, but it has been unclear how two DNA sensors could both be required for...
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| Publicado en: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2015
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4394261/ https://ncbi.nlm.nih.gov/pubmed/25831530 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1424637112 |
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