Analysis of Mll1-deficiency identifies neurogenic transcriptional modules and Brn4 as a factor for direct astrocyte-to-neuron reprogramming

BACKGROUND: Mixed lineage leukemia-1 (Mll1) epigenetically regulates gene expression patterns that specify cellular identity in both embryonic development and adult stem cell populations. In the adult mouse brain, multipotent neural stem cells (NSCs) in the subventricular zone (SVZ) generate new neu...

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Détails bibliographiques
Publié dans:Neurosurgery
Auteurs principaux: Potts, Matthew B., Siu, Jason J., Price, James D., Salinas, Ryan D., Cho, Mathew J., Ramos, Alexander D., Hahn, Junghyun, Margeta, Marta, Oldham, Michael C., Lim, Daniel A.
Format: Artigo
Langue:Inglês
Publié: 2014
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4420187/
https://ncbi.nlm.nih.gov/pubmed/24887289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1227/NEU.0000000000000452
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