Transcellular delivery of vesicular SOCS proteins from macrophages to epithelial cells blunts inflammatory signaling

JAK-STAT signaling mediates the actions of numerous cytokines and growth factors, and its endogenous brake is the family of SOCS proteins. Consistent with their intracellular roles, SOCS proteins have never been identified in the extracellular space. Here we report that alveolar macrophages can secr...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Bourdonnay, Emilie, Zasłona, Zbigniew, Penke, Loka Raghu Kumar, Speth, Jennifer M., Schneider, Daniel J., Przybranowski, Sally, Swanson, Joel A., Mancuso, Peter, Freeman, Christine M., Curtis, Jeffrey L., Peters-Golden, Marc
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4419346/
https://ncbi.nlm.nih.gov/pubmed/25847945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20141675
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