Metabolic reprogramming in triple-negative breast cancer through Myc suppression of TXNIP

Triple-negative breast cancers (TNBCs) are aggressive and lack targeted therapies. Understanding how nutrients are used in TNBCs may provide new targets for therapeutic intervention. We demonstrate that the transcription factor c-Myc drives glucose metabolism in TNBC cells but does so by a previousl...

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Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: Shen, Liangliang, O’Shea, John M., Kaadige, Mohan R., Cunha, Stéphanie, Wilde, Blake R., Cohen, Adam L., Welm, Alana L., Ayer, Donald E.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2015
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4418882/
https://ncbi.nlm.nih.gov/pubmed/25870263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1501555112
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