Crystalline silica-induced leukotrieneB(4)-dependent inflammation promotes lung tumor growth

Chronic exposure to crystalline silica (CS) causes silicosis, an irreversible lung inflammatory disease that may eventually lead to lung cancer. In this study, we demonstrate that in K-ras(LA1) mice, CS exposure markedly enhances the lung tumor burden and genetic deletion of leukotriene B(4) recepto...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Commun
Prif Awduron: Satpathy, Shuchismita R., Jala, Venkatakrishna R., Bodduluri, Sobha R., Krishnan, Elangovan, Hegde, Bindu, Hoyle, Gary, Fraig, Mostafa, Luster, Andrew D., Haribabu, Bodduluri
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2015
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4418220/
https://ncbi.nlm.nih.gov/pubmed/25923988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8064
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg