A single dose of a neuron-binding human monoclonal antibody improves brainstem NAA concentrations, a biomarker for density of spinal cord axons, in a model of progressive multiple sclerosis

BACKGROUND: Intracerebral infection of susceptible mouse strains with Theiler’s murine encephalomyelitis virus (TMEV) results in chronic demyelinating disease with progressive axonal loss and neurologic dysfunction similar to progressive forms of multiple sclerosis (MS). We previously showed that as...

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Detaylı Bibliyografya
Yayımlandı:J Neuroinflammation
Asıl Yazarlar: Wootla, Bharath, Denic, Aleksandar, Watzlawik, Jens O, Warrington, Arthur E, Rodriguez, Moses
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2015
Konular:
Short Report
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4418041/
https://ncbi.nlm.nih.gov/pubmed/25924771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-015-0303-y
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