IL-2 Inducible T-cell Kinase, a Novel Therapeutic Target in Melanoma

PURPOSE: Interleukin-2 inducible T-cell kinase (ITK) promoter CpG sites are hypomethylated in melanomas compared to nevi. The expression of ITK in melanomas, however, has not been established and requires elucidation. EXPERIMENTAL DESIGN: An ITK specific monoclonal antibody was used to probe section...

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Published in:Clin Cancer Res
Main Authors: Carson, Craig C., Moschos, Stergios J., Edmiston, Sharon N., Darr, David B., Nikolaishvili-Feinberg, Nana, Groben, Pamela A., Zhou, Xin, Kuan, Pei Fen, Pandey, Shaily, Chan, Keefe T., Jordan, Jamie L., Hao, Honglin, Frank, Jill S., Hopkinson, Dennis A., Gibbs, David C., Alldredge, Virginia D., Parrish, Eloise, Hanna, Sara C., Berkowitz, Paula, Rubenstein, David S., Miller, C. Ryan, Bear, James E., Ollila, David W., Sharpless, Norman E., Conway, Kathleen, Thomas, Nancy E.
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4418029/
https://ncbi.nlm.nih.gov/pubmed/25934889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-14-1826
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