IL-2 Inducible T-cell Kinase, a Novel Therapeutic Target in Melanoma

PURPOSE: Interleukin-2 inducible T-cell kinase (ITK) promoter CpG sites are hypomethylated in melanomas compared to nevi. The expression of ITK in melanomas, however, has not been established and requires elucidation. EXPERIMENTAL DESIGN: An ITK specific monoclonal antibody was used to probe section...

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Pubblicato in:Clin Cancer Res
Autori principali: Carson, Craig C., Moschos, Stergios J., Edmiston, Sharon N., Darr, David B., Nikolaishvili-Feinberg, Nana, Groben, Pamela A., Zhou, Xin, Kuan, Pei Fen, Pandey, Shaily, Chan, Keefe T., Jordan, Jamie L., Hao, Honglin, Frank, Jill S., Hopkinson, Dennis A., Gibbs, David C., Alldredge, Virginia D., Parrish, Eloise, Hanna, Sara C., Berkowitz, Paula, Rubenstein, David S., Miller, C. Ryan, Bear, James E., Ollila, David W., Sharpless, Norman E., Conway, Kathleen, Thomas, Nancy E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4418029/
https://ncbi.nlm.nih.gov/pubmed/25934889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-14-1826
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