Association of Valine and Leucine at HLA–DRB1 Position 11 With Radiographic Progression in Rheumatoid Arthritis, Independent of the Shared Epitope Alleles but Not Independent of Anti–Citrullinated Protein Antibodies

OBJECTIVE: For decades it has been known that the HLA–DRB1 shared epitope (SE) alleles are associated with an increased risk of development and progression of rheumatoid arthritis (RA). Recently, the following variations in the peptide-binding grooves of HLA molecules that predispose to RA developme...

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Publicado no:Arthritis Rheumatol
Main Authors: van Steenbergen, H. W., Raychaudhuri, S., Rodríguez-Rodríguez, L., Rantapää-Dahlqvist, S., Berglin, E., Toes, R. E. M., Huizinga, T. W. J., Fernández-Gutiérrez, B., Gregersen, P. K., van der Helm-van Mil, A. H. M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4417503/
https://ncbi.nlm.nih.gov/pubmed/25580908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.39018
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