Modulation of deoxycytidine kinase (dCK) and glycogen synthase kinase (GSK-3β) by anti-CD20 (rituximab) and 2-chlorodeoxyadenosine (2-CdA) in human lymphoid malignancies

BACKGROUND: The combination of rituximab and 2-CdA is an effective therapy for B-cell tumors. However, the molecular mechanisms and enzymatic pathways involved in the interaction between the two agents are not fully understood. In this study, we provide molecular evidence for positive interaction be...

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Sparad:
Bibliografiska uppgifter
I publikationen:Exp Hematol Oncol
Huvudupphovsmän: Al-Katib, Ayad M, Aboukameel, Amro, Ebrahim, AbdulShukkur, Beck, Frances WJ, Tekyi-Mensah, Samuel E, Raufi, Ali, Ahmed, Yasin, Mandziara, Mary, Kafri, Zyad
Materialtyp: Artigo
Språk:Inglês
Publicerad: BioMed Central 2014
Ämnen:
Research
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4417330/
https://ncbi.nlm.nih.gov/pubmed/25937997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2162-3619-3-31
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