Copy-neutral loss of heterozygosity and chromosome gains and losses are frequent in gastrointestinal stromal tumors

BACKGROUND: A KIT gain of function mutation is present in 70% of gastrointestinal stromal tumors (GISTs) and the wild-type (WT) allele is deleted in 5 to 15% of these cases. The WT KIT is probably deleted during GIST progression. We aimed to identify the mechanism of WT KIT loss and to determine whe...

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Detalhes bibliográficos
Publicado no:Mol Cancer
Main Authors: Lourenço, Nelson, Hélias-Rodzewicz, Zofia, Bachet, Jean-Baptiste, Brahimi-Adouane, Sabrina, Jardin, Fabrice, Tran van Nhieu, Jeanne, Peschaud, Frédérique, Martin, Emmanuel, Beauchet, Alain, Chibon, Frédéric, Emile, Jean-François
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4417285/
https://ncbi.nlm.nih.gov/pubmed/25373456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-13-246
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