Molecular crowding enhances facilitated diffusion of two human DNA glycosylases

Intracellular space is at a premium due to the high concentrations of biomolecules and is expected to have a fundamental effect on how large macromolecules move in the cell. Here, we report that crowded solutions promote intramolecular DNA translocation by two human DNA repair glycosylases. The crow...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Cravens, Shannen L., Schonhoft, Joseph D., Rowland, Meng M., Rodriguez, Alyssa A., Anderson, Breeana G., Stivers, James T.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2015
Subjects:
Genome Integrity, Repair and Replication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4417188/
https://ncbi.nlm.nih.gov/pubmed/25845592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv301
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