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The NEIL glycosylases remove oxidized guanine lesions from telomeric and promoter quadruplex DNA structures
G-quadruplex is a four-stranded G-rich DNA structure that is highly susceptible to oxidation. Despite the important roles that G-quadruplexes play in telomere biology and gene transcription, neither the impact of guanine lesions on the stability of quadruplexes nor their repair are well understood....
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| Publicado no: | Nucleic Acids Res |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4417164/ https://ncbi.nlm.nih.gov/pubmed/25813041 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv252 |
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