Fluorescence Resonance Energy Transfer (FRET) and Proximity Ligation Assays Reveal Functionally Relevant Homo- and Heteromeric Complexes among Hyaluronan Synthases HAS1, HAS2, and HAS3

In vertebrates, hyaluronan is produced in the plasma membrane from cytosolic UDP-sugar substrates by hyaluronan synthase 1–3 (HAS1–3) isoenzymes that transfer N-acetylglucosamine (GlcNAc) and glucuronic acid (GlcUA) in alternative positions in the growing polysaccharide chain during its simultaneous...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Bart, Geneviève, Vico, Nuria Ortega, Hassinen, Antti, Pujol, Francois M., Deen, Ashik Jawahar, Ruusala, Aino, Tammi, Raija H., Squire, Anthony, Heldin, Paraskevi, Kellokumpu, Sakari, Tammi, Markku I.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Glycobiology and Extracellular Matrices
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4416852/
https://ncbi.nlm.nih.gov/pubmed/25795779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.640581
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