Recovery of Recombinant Crimean Congo Hemorrhagic Fever Virus Reveals a Function for Non-structural Glycoproteins Cleavage by Furin

Crimean Congo hemorrhagic fever virus (CCHFV) is a negative-strand RNA virus of the family Bunyaviridae (genus: Nairovirus). In humans, CCHFV causes fever, hemorrhage, severe thrombocytopenia, and high fatality. A major impediment in precisely determining the basis of CCHFV’s high pathogenicity has...

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Pubblicato in:PLoS Pathog
Autori principali: Bergeron, Éric, Zivcec, Marko, Chakrabarti, Ayan K., Nichol, Stuart T., Albariño, César G., Spiropoulou, Christina F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4416775/
https://ncbi.nlm.nih.gov/pubmed/25933376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004879
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