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PET imaging of HSV1-tk mutants with acquired specificity toward pyrimidine- and acycloguanosine-based radiotracers

PURPOSE: The aim of this study was to create an alternative mutant of the herpes simplex virus type 1 thymidine kinase (HSV1-tk) reporter gene with reduced phosphorylation capacity for acycloguanosine derivatives, but not pyrimidine-based compounds that will allow for successful PET imaging. METHODS...

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Bibliografiske detaljer
Udgivet i:Eur J Nucl Med Mol Imaging
Main Authors: Likar, Yury, Dobrenkov, Konstantin, Olszewska, Malgorzata, Shenker, Larissa, Cai, Shangde, Hricak, Hedvig, Ponomarev, Vladimir
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4416642/
https://ncbi.nlm.nih.gov/pubmed/19259663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00259-009-1089-x
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