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Different strategies for reducing intestinal background radioactivity associated with imaging HSV1-tk expression using established radionucleoside probes

One limitation of HSV1-tk reporter PET imaging with nucleoside analogues is the high background radioactivity in the intestine. We hypothesized that endogenous expression of thymidine kinase in bacterial flora could phosphorylate and trap such radiotracers, contributing to the high radioactivity lev...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Ruggiero, Alessandro, Brader, Peter, Serganova, Inna, Zanzonico, Pat, Cai, Shangde, Lipman, Neil S., Hricak, Hedvig, Blasberg, Ronald G.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2010
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3068838/
https://ncbi.nlm.nih.gov/pubmed/20128998
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