Cytoplasmically Retargeted HSV1-tk/GFP Reporter Gene Mutants for Optimization of Noninvasive Molecular-Genetic Imaging

To optimize the sensitivity of imaging HSV1-tk/GFP reporter gene expression, a series of HSV1-tk/GFP mutants was developed with altered nuclear localization and better cellular enzymatic activity, compared to that of the native HSV1-tk/GFP fusion protein (HSV1-tk/GFP). Several modifications of HSV1-...

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Bibliografiske detaljer
Main Authors: Ponomarev, Vladimir, Doubrovin, Michael, Serganova, Inna, Beresten, Tatiana, Vider, Jelena, Shavrin, Aleksander, Ageyeva, Ludmila, Balatoni, Julius, Blasberg, Ronald, Tjuvajev, Juri Gelovani
Format: Artigo
Sprog:Inglês
Udgivet: Neoplasia Press Inc. 2003
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1502405/
https://ncbi.nlm.nih.gov/pubmed/12869307
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