Brain-mediated antidiabetic, anorexic, and cardiovascular actions of leptin require melanocortin-4 receptor signaling

We previously demonstrated that leptin has powerful central nervous system (CNS)-mediated antidiabetic actions. In this study we tested the importance of melanocortin-4 receptors (MC4Rs) for leptin's ability to suppress food intake, increase blood pressure (BP) and heart rate (HR), and normaliz...

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Pubblicato in:J Neurophysiol
Autori principali: da Silva, Alexandre A., Spradley, Frank T., Granger, Joey P., Hall, John E., do Carmo, Jussara M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2015
Soggetti:
Control of Homeostasis
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4416609/
https://ncbi.nlm.nih.gov/pubmed/25717164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/jn.00911.2014
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