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Energy landscapes of functional proteins are inherently risky
Evolutionary pressure for protein function leads to unavoidable sampling of conformational states that are at risk of misfolding and aggregation. The resulting tension between functional requirements and the risk of misfolding and/or aggregation in the evolution of proteins is becoming more and more...
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| Publicado no: | Nat Chem Biol |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4416114/ https://ncbi.nlm.nih.gov/pubmed/25325699 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1670 |
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