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Macromolecular crowding remodels the energy landscape of a protein by favoring a more compact unfolded state
The interior of cells is highly crowded with macromolecules, which impacts all physiological processes. To explore how macromolecular crowding may influence cellular protein folding, we interrogated the folding landscape of a model β-rich protein, cellular retinoic acid-binding protein I (CRABP I),...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2921862/ https://ncbi.nlm.nih.gov/pubmed/20662522 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja103166y |
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