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Selective inhibition of KCa3.1 channels mediates adenosine regulation of the motility of human T cells

Adenosine, a purine nucleoside, is present at high concentrations in tumors where it contributes to the failure of immune cells to eliminate cancer cells. The mechanisms responsible for the immunosuppressive properties of adenosine are not fully understood. We tested the hypothesis that adenosine’s...

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Publicat a:J Immunol
Autors principals: Chimote, Ameet A., Hajdu, Peter, Kucher, Vladimir, Boiko, Nina, Kuras, Zerrin, Szilagyi, Orsolya, Yun, Yeo-Heung, Conforti, Laura
Format: Artigo
Idioma:Inglês
Publicat: 2013
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4415878/
https://ncbi.nlm.nih.gov/pubmed/24227782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1300702
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