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Lipophilic Triphenylphosphonium Cations Inhibit Mitochondrial Electron Transport Chain and Induce Mitochondrial Proton Leak
BACKGROUND: The lipophilic positively charged moiety of triphenylphosphonium (TPP(+)) has been used to target a range of biologically active compounds including antioxidants, spin-traps and other probes into mitochondria. The moiety itself, while often considered biologically inert, appears to influ...
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| Publicado en: | PLoS One |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Public Library of Science
2015
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4415762/ https://ncbi.nlm.nih.gov/pubmed/25927600 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0121837 |
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