Characterizing the PK/PD relationship for inhibition of capsaicin-induced dermal vasodilatation by MK-3207, an oral calcitonin gene related peptide receptor antagonist

AIMS: Calcitonin gene related peptide (CGRP) receptor antagonists are effective acute migraine treatments. A capsaicin-induced dermal vasodilatation (CIDV) model has been developed to provide target-engagement information in healthy volunteers. In the model, CGRP release is provoked after dermal cap...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Br J Clin Pharmacol
Autori principali: Li, Chi-Chung, Vermeersch, Steve, Denney, William S, Kennedy, William P, Palcza, John, Gipson, Adrianna, Han, Tae H, Blanchard, Rebecca, De Lepeleire, Inge, Depré, Marleen, Murphy, M Gail, Van Dyck, Kristien, de Hoon, Jan N
Natura: Artigo
Lingua:Inglês
Pubblicazione: BlackWell Publishing Ltd 2015
Soggetti:
Pk-Pd Relationships
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4415719/
https://ncbi.nlm.nih.gov/pubmed/25377933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12547
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