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Enhanced tethered-flight duration and locomotor activity by overexpression of the human gene SOD1 in Drosophila motorneurons

Mutation of the human gene superoxide dismutase (hSOD1) is associated with the fatal neurodegenerative disease familial amyotrophic lateral sclerosis (Lou Gehrig’s disease). Selective overexpression of hSOD1 in Drosophila motorneurons increases lifespan to 140% of normal. The current study was desig...

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發表在:Genet Mol Biol
Main Authors: Petrosyan, Agavni, Hsieh, I-Hui, Phillips, John P., Saberi, Kourosh
格式: Artigo
語言:Inglês
出版: Sociedade Brasileira de Genética 2015
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4415569/
https://ncbi.nlm.nih.gov/pubmed/25983632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1590/S1415-475738138120140132
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