Beyond GWAS in COPD: Probing the landscape between gene-set associations, genome-wide associations and protein-protein interaction networks

OBJECTIVES: To use a systems biology approach to integrate genotype and protein-protein interaction (PPI) data to identify disease network modules associated with chronic obstructive pulmonary disease (COPD) and to perform traditional pathway analysis. METHODS: We used a standard gene-set associatio...

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Udgivet i:Hum Hered
Main Authors: McDonald, Merry-Lynn Noelle, Mattheisen, Manuel, Cho, Michael H., Liu, Yang-Yu, Harshfield, Benjamin, Hersh, Craig P., Bakke, Per, Gulsvik, Amund, Lange, Christoph, Beaty, Terri H., Silverman, Edwin K.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4415367/
https://ncbi.nlm.nih.gov/pubmed/25171373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000365589
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