The pathogenic human Torsin A in Drosophila activates the unfolded protein response and increases susceptibility to oxidative stress

BACKGROUND: Dystonia1 (DYT1) dystonia is caused by a glutamic acid deletion (ΔE) mutation in the gene encoding Torsin A in humans (HTorA). To investigate the unknown molecular and cellular mechanisms underlying DYT1 dystonia, we performed an unbiased proteomic analysis. RESULTS: We found that the am...

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Detalhes bibliográficos
Publicado no:BMC Genomics
Main Authors: Kim, A-Young, Seo, Jong Bok, Kim, Won-tae, Choi, Hee Jeong, Kim, Soo-Young, Morrow, Genevieve, Tanguay, Robert M, Steller, Hermann, Koh, Young Ho
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4415242/
https://ncbi.nlm.nih.gov/pubmed/25903460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12864-015-1518-0
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