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Unfolded protein response in Gaucher disease: from human to Drosophila
BACKGROUND: In Gaucher disease (GD), resulting from mutations in the GBA gene, mutant β-glucocerebrosidase (GCase) molecules are recognized as misfolded in the endoplasmic reticulum (ER). They are retrotranslocated to the cytoplasm, where they are ubiquitinated and undergo proteasomal degradation in...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3819655/ https://ncbi.nlm.nih.gov/pubmed/24020503 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1172-8-140 |
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