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Modulation of conformational changes in helix 69 mutants by pseudouridine modifications

Centrally located at the ribosomal subunit interface and mRNA tunnel, helix 69 (H69) from 23S rRNA participates in key steps of translation. Ribosome activity is influenced by three pseudouridine modifications, which modulate the structure and conformational behavior of H69. To understand how H69 is...

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Veröffentlicht in:Biophys Chem
Hauptverfasser: Jiang, Jun, Kharel, Daya Nidhi, Chow, Christine S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4414897/
https://ncbi.nlm.nih.gov/pubmed/25800680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpc.2015.03.001
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