Abnormal contractile properties of muscle fibers expressing beta-myosin heavy chain gene mutations in patients with hypertrophic cardiomyopathy.

Missense mutations in the beta-myosin heavy chain (beta-MHC) gene cause hypertrophic cardiomyopathy (HCM). As normal and mutant beta-MHCs are expressed in slow-twitch skeletal muscle of HCM patients, we compared the contractile properties of single slow-twitch muscle fibers from patients with three...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Lankford, E B, Epstein, N D, Fananapazir, L, Sweeney, H L
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 1995
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC441484/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7883988/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI117795
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