Susceptibility to tuberculosis is associated with variants in the ASAP1 gene encoding a regulator of dendritic cell migration

Human genetic factors predispose to tuberculosis (TB). We studied 7.6 million genetic variants in 5,530 pulmonary TB patients and 5,607 healthy controls. In the combined analysis of these subjects and the follow-up cohort (15,087 TB patients and controls altogether), we found association between TB...

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Vydáno v:Nat Genet
Hlavní autoři: Curtis, James, Luo, Yang, Zenner, Helen L., Cuchet-Lourenço, Delphine, Wu, Changxin, Lo, Kitty, Maes, Mailis, Alisaac, Ali, Stebbings, Emma, Liu, Jimmy Z., Kopanitsa, Liliya, Ignatyeva, Olga, Balabanova, Yanina, Nikolayevskyy, Vladyslav, Baessmann, Ingelore, Thye, Thorsten, Meyer, Christian G., Nürnberg, Peter, Horstmann, Rolf D., Drobniewski, Francis, Plagnol, Vincent, Barrett, Jeffrey C., Nejentsev, Sergey
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4414475/
https://ncbi.nlm.nih.gov/pubmed/25774636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3248
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