Posttranscriptional stabilization underlies p53-independent induction of p21WAF1/CIP1/SDI1 in differentiating human leukemic cells.

p21WAF/CIP1/SDI1 is a recently identified gene expressed in cells harboring wild-type but not mutant p53 gene. It encodes a nuclear protein of 21 kD which inhibits cyclin-dependent kinase activity. Constitutive p21WAF1/CIP1/SDI1 mRNA expression was detected in neoplastic cells from patients with var...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Schwaller, J, Koeffler, H P, Niklaus, G, Loetscher, P, Nagel, S, Fey, M F, Tobler, A
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 1995
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC441429/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7883998/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI117806
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