Associations between host gene expression, the mucosal microbiome, and clinical outcome in the pelvic pouch of patients with inflammatory bowel disease

BACKGROUND: Pouchitis is common after ileal pouch-anal anastomosis (IPAA) surgery for ulcerative colitis (UC). Similar to inflammatory bowel disease (IBD), both host genetics and the microbiota are implicated in its pathogenesis. We use the IPAA model of IBD to associate mucosal host gene expression...

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Detalhes bibliográficos
Publicado no:Genome Biol
Main Authors: Morgan, Xochitl C, Kabakchiev, Boyko, Waldron, Levi, Tyler, Andrea D, Tickle, Timothy L, Milgrom, Raquel, Stempak, Joanne M, Gevers, Dirk, Xavier, Ramnik J, Silverberg, Mark S, Huttenhower, Curtis
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4414286/
https://ncbi.nlm.nih.gov/pubmed/25887922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-015-0637-x
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