Inhibition of ERK1/2 down-regulates the Hippo/YAP signaling pathway in human NSCLC cells

Alterations of the EGFR/ERK and Hippo/YAP pathway have been found in non-small cell lung cancer (NSCLC). Herein, we show that ERK1 and ERK2 have an effect on the Hippo/YAP pathway in human NSCLC cells. Firstly, inhibition of ERK1/2 by siRNA or small-molecular inhibitors decreased the YAP protein lev...

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Veröffentlicht in:Oncotarget
Hauptverfasser: You, Bin, Yang, Yi-Lin, Xu, Zhidong, Dai, Yuyuan, Liu, Shu, Mao, Jian-Hua, Tetsu, Osamu, Li, Hui, Jablons, David M., You, Liang
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2015
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4414195/
https://ncbi.nlm.nih.gov/pubmed/25738359
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