Accumulation of FOXP3+T-cells in the tumor microenvironment is associated with an epithelial-mesenchymal-transition-type tumor budding phenotype and is an independent prognostic factor in surgically resected pancreatic ductal adenocarcinoma

Here we explore the role of the interplay between host immune response and epithelial-mesenchymal-transition (EMT)-Type tumor-budding on the outcome of pancreatic adenocarcinoma (PDAC). CD4+, CD8+, and FOXP3+T-cells as well as iNOS+ (M1) and CD163+-macrophages (M2) were assessed on multipunch tissue...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Wartenberg, Martin, Zlobec, Inti, Perren, Aurel, Koelzer, Viktor Hendrik, Gloor, Beat, Lugli, Alessandro, Eva, Karamitopoulou
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2015
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4414182/
https://ncbi.nlm.nih.gov/pubmed/25669968
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