Autophagy through 4EBP1 and AMPK regulates oxidative stress-induced premature senescence in auditory cells

The aim of this study was to determine whether autophagy and AMPK contribute to premature senescence in auditory cells. Incubating HEI-OC1 auditory cells with 5 mM H(2)O(2) for 1 h induced senescence, as demonstrated by senescence-associated β-galactosidase (SA-β-gal) staining. H(2)O(2) treatment si...

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Détails bibliographiques
Publié dans:Oncotarget
Auteurs principaux: Tsuchihashi, Nana Akagi, Hayashi, Ken, Dan, Katsuaki, Goto, Fumiyuki, Nomura, Yasuyuki, Fujioka, Masato, Kanzaki, Sho, Komune, Shizuo, Ogawa, Kaoru
Format: Artigo
Langue:Inglês
Publié: Impact Journals LLC 2014
Sujets:
Gerotarget (Focus on Aging): Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4414143/
https://ncbi.nlm.nih.gov/pubmed/25682865
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