Long-term treatment with imatinib results in profound mast cell deficiency in Ph+ chronic myeloid leukemia

Although mast cells (MC) play an important role in allergic reactions, their physiologic role remains unknown. In mice, several models of MC-deficiency have been developed. However, no comparable human model is available. We examined the in vitro- and in vivo effects of the KIT-targeting drug imatin...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Cerny-Reiterer, Sabine, Rabenhorst, Anja, Stefanzl, Gabriele, Herndlhofer, Susanne, Hoermann, Gregor, Müllauer, Leonhard, Baumgartner, Sigrid, Beham-Schmid, Christine, Sperr, Wolfgang R, Mannhalter, Christine, Sill, Heinz, Linkesch, Werner, Arock, Michel, Hartmann, Karin, Valent, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2014
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4413638/
https://ncbi.nlm.nih.gov/pubmed/25605011
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