12/15 lipoxygenase regulation of colorectal tumorigenesis is determined by the relative tumor levels of its metabolite 12-HETE and 13-HODE in animal models

Colorectal cancer (CRC) continues to be a major cause of morbidity and mortality. The arachidonic acid (AA) pathway and linoleic acid (LA) pathway have been implicated as important contributors to CRC development and growth. Human 15-lipoxygenase 1 (15-LOX-1) converts LA to anti-tumor 13-S-hydroxyoc...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Chang, Jian, Jiang, Li, Wang, Yinqiu, Yao, Bing, Yang, Shilin, Zhang, Bixiang, Zhang, Ming-Zhi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2014
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4413624/
https://ncbi.nlm.nih.gov/pubmed/25576922
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