Folate-mediated mitochondrial targeting with doxorubicin-polyrotaxane nanoparticles overcomes multidrug resistance

Resistance to treatment with anticancer drugs is a significant obstacle and a fundamental cause of therapeutic failure in cancer therapy. Functional doxorubicin (DOX) nanoparticles for targeted delivery of the classical cytotoxic anticancer drug DOX to tumor cells, using folate-terminated polyrotaxa...

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Udgivet i:Oncotarget
Main Authors: Wang, He, Yin, Henghui, Yan, Fengjiao, Sun, Mingna, Du, Lingran, Peng, Wei, Li, Qiuli, Feng, Yinghong, Zhou, Yi
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2014
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4413620/
https://ncbi.nlm.nih.gov/pubmed/25605018
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